See the question and my original answer on StackOverflow

When you have a good discriminant (which you pointed out in the comment), for example a CLASS attribute, XPATH is an easy way to query the HTML DOM, like this:

   Dim question As String = "what time is it"
   Dim web As New HtmlWeb
   Console.WriteLine(web.Load(("http://wiki.answers.com/Q/" & question)).DocumentNode.SelectSingleNode("//div[@class='answer_text']").InnerText.Trim)